Sunday, October 7, 2001

15:00 - 18:00 Registration

16:00 - 18:00 Linking the Pharmaceutical Industry with Academia
Pre-conference Workshop (an Adobe pdf file)
by PricewaterhouseCoopers, Basel, Switzerland
Workshop Co-Chairs:
Andreas Fischer and Andreas Wickli

18:00 - 19:30 Opening Dinner

19:30 - 19:45 Opening Remarks
Conference Co-Chair: F. W. Scheller, University of Potsdam, GERMANY
UEF Liaison: Allen Laskin, New York, USA

19:45 - 20:45 Plenary Lecture
Hartmut. Michel, (Nobel Prize Laureate), Frankfurt, GERMANY

21:00 - 22.00 Opening Reception

Monday, October 8, 2001

07:00 - 08:15 Breakfast

08:30 - 12:00 SESSION I: INDUSTRIAL BIOCATALYSIS
Session Co-Chairs:
Christian Wandrey, Jülich Research Centre, Jülich, GERMANY
Poul .B. Poulsen, NOVOZYMES, Bagsvaerd, DENMARK

08:30 - 09:00 Industrial Biocatalysis - The American View from Academia
Chi Huey Wong, The Scripps Research Institute, La Jolla, USA

09:00 - 09:30 Industrial Biocatalysis - The American View from Industry
Keith A. Powell, Maxygen Inc., Redwood City, USA

09:30 - 10:00 Industrial Biocatalysis - The Asian View from Academia
Sakayu Shimizu, Kyoto University, Kyoto, JAPAN

10:00 - 10:30 Coffee Break

10:30 - 11:00 Industrial Biocatalysis - The Asian View from Industry
Junzo Hasegawa, KANEKA Corp, Osaka, JAPAN

11:00 - 11:30 Industrial Biocatalysis - The European View from Academia
Herfried Griengl, Graz Technical University, Graz, AUSTRIA

11:30 - 12:00 Industrial Biocatalysis - The European View from Industry
Johan Kamphuis, DSM Food Specialties, Delft, THE NETHERLANDS

12:00 - 13:00 Lunch

13:30 - 17:30 Visit to Potsdam/ad hoc Session at Potsdam University
Session Chair:
Oreste Ghisalba, Novartis Pharma AG, Basel, SWITZERLAND

Biotechnology for Clean Industrial Products and Processes - The OECD View
Alan T. Bull, University of Kent, UNITED KINGDOM

17:30 - 19:30 POSTER SESSION I
Session Chair:
Harvey W. Blanch, University of California, Berkeley, USA
(Presenters will be present to answer questions)

19:30 - 21:00 Dinner

21:00 - 22:30 Social hour (in poster area)

Tuesday, October 9, 2001

07:00 - 08:15 Breakfast

08:30 - 12:00 SESSION II: ANALYTICAL APPLICATIONS
Session Co-Chairs:
Gao Xiang Li, Institute of Microbiology, Chinese Academy of Sciences, Beijing, CHINA
Reinhard Renneberg, Hong Kong University of Science and Technology, Hong Kong, CHINA

08:30 - 09:00 Imaging Cytochrome P450: The Scanning Tunnelling Microscopy
of Redox Active Proteins
H. Allen O. Hill, Oxford, UNITED KINGDOM

09:00 - 09:30 Enzyme Catalysis at the Single Molecule Level
Rudolf Rigler, Karolinska Institute, Stockholm, SWEDEN

09:30 - 10:00 Molecular Enzyme Engineering for Biosensors and Biochips
Xian-En Zhang, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, CHINA

10:00 - 10:30 Coffee Break

10:30 - 11:00 The Development of an Interface Protein to Facilitate the
Electron Transfer Between Sensor Enzyme and Electro-Chemical Reaction -
The Artificial Electron Transfer Subunit
Koji Sode, Tokyo University of Agriculture and Technology, Tokyo, JAPAN

11:00 - 11:30 TBA

11:30 - 12:00 Discussion

12:00 - 13:00 Lunch

14:00 - 17:00 SESSION III: NEW BIOCATALYSTS
Session Co-Chairs:
Yasuhisa Asano, Toyama Prefectural University, JAPAN
Johannes Paul Pachlatko, Syngenta AG, Basel, SWITZERLAND

14:00 - 14:30 Recombinant Human P450 Enzymes for the Generation of Phase I
Drug Metabolites
Thomas Friedberg, University of Dundee, UNITED KINGDOM

14:30 - 15:00 Exploring the Substrate Spectrum of Recombinant Sucrose Synthase
for Carbohydrate Engineering
Lothar Elling, Heinrich-University of Düsseldorf, GERMANY

15:00 - 15:30 Enzymatic-Synthesis of Non-Protein Amino Acids Using Cystein Synthetase
Coupled with Acetyl-CoA Regeneration
Kazuhiro Nakanishi, Okayama University, JAPAN

15:30 - 16:00 Coffee Break

16:00 - 16:30 Synthesis of Cephalexin from D-Amino-2-Phenylacetonitrile
Using an Enzymatic Cascade
Fred van Rantwijk, Delft University of Technology, THE NETHERLANDS

16:30 - 17:00 Directec Evolution of Hydroxynitrillyase toward Improved
Activity with Bulky Substrates
Helmut Schwab, Technical University of Graz, AUSTRIA

17:00 - 19:30 POSTER SESSION II
Session Chair:
Hak-Sung Kim, Korea Advanced Institute of Science and Technology, Taejon, KOREA
(Poster presenters will be present to answer questions)

19:30 - 21:00 Dinner

21:00 - 22:00 Social hour (in poster area)

Wednesday, October 10, 2001

07:00 - 08:15 Breakfast

08:30 - 12:00 SESSION IV: DIRECTED EVOLUTION OF BIOCATALYSTS
Session Chair:
Frances H. Arnold, Caltech, Pasadena, USA

08:30 - 09:00 The Limits of Thermotolerance
Andrew Ellington, University of Texas, Austin, USA

09:00 - 09:30 Molecular Breeding of Enzymes, Pathways and Whole Microbes
by DNA Shuffling
Willem P.C. Stemmer, Maxygen, Inc., Redwood City, USA

09:30 - 10:00 Laboratory Evolution of Cytochrome P450
Frances H. Arnold, Caltech, Pasadena, USA

10:00 - 10:30 Coffee Break

10:30 - 11:00 Molecular Breeding of Biosynthetic Pathways
Claudia Schmidt-Dannert, University of Minnesota, St. Paul, USA

11:00 - 11:30 Creation of Enantioselective Lipases by Directed Evolution
Karl-Erich Jaeger, Ruhr University of Bochum, GERMANY

11:30 - 12:00 Discussion

12:00 - 18:00 Lunch/Tour to Berlin

19:00 - 20:30 Dinner

20:30 - 22:30 Social hour (in poster area)

Thursday, October 11, 2001

07:00 - 08:15 Breakfast

08:30 - 12:00 SESSION V: STRUCTURE/CATALYTIC MECHANISMS
Session Co-Chairs:
Jean-Pierre Toutant, OECD Coordinator, Montpellier, FRANCE
Joel L. Sussman, Rehovot, ISRAEL

08:30 - 09:00 Acetylcholinesterase: Is It Possible to Infer Alternate Functions for this
Enzyme from Its 3D Structure?
Joel I. Sussman, The Weizmann Institute of Science, Rehovot, ISRAEL

09:00 - 09:30 Substrate Recognition Scheme of Glycosyltrehalose Trehalohydrolase from
the Hyperthermophilic Archaeum Sulfolobus Solfataricus
Michael D. Feese, Emerald BioStructures, Inc., USA

09:30 - 10:00 Cyclic Amidases, New 3D-Structures of Enzymes with Biotechnological
Interest
Dietmar Schomburg, University of Cologne, GERMANY

10:00 - 10:30 Coffee Break

10:30 - 11:00 Structures and Mechanisms of Chitinases
M.G. Peter, University of Potsdam, GERMANY

11:00 - 11:30 Characterization, Sequencing and Protein Engineering of Cryophilic
Proteases of Marine Origin
J.A. Asenjo, University of Chile, Santiago, CHILE

11:30 - 12:00 Discussion

12:00 - 13:00 Lunch

13:30 - 16.30 SESSION VI: WORKSHOP NEW TECHNIQUES
Session Co-Chairs:
Maria-Regina Kula, Reinrich-University of Düsseldorf, GERMANY
Oreste Ghisalba, Novartis Pharma AG, Basel, SWITZERAND

13:30 - 13:45 Investigation and on-line Analysis of Enantioselective Enzymatic Reactions
in Different Solvents via 2D-Fluorescence Spectroscopy
Torsten Knüttel, University of Hannover, GERMANY

13:45 - 14:00 Gas Phase Biotransformations Catalysed by Whole Cells
Isabelle Goubet, Université de la Rochelle, FRANCE

14:00 - 14:15 New Strategies for Enzyme Stabilization Involving the Protein Engineering
and the Immobilization in Mesoporous Materials
Haruo Takahashi, TOYOTA Central R&D Laboratories, Aichi, JAPAN

14:15 - 14:30 A Novel Transglutaminase from Bacillus subtilis Spores
Kenzo Yokozeki, Ajinomoto Co, JAPAN

14:30 - 14:45 Stabilization of NAD-dependent Formate Dehydrogenase from Candida
boidinii by Directed Evolution
Heike Slusarczyk, Heinrich-Heine-University of Düsseldorf, GERMANY

14:45 - 15:00 A Novel Molecularly Imprinted Catalyst Mimicking a Fructosyl Amine
Dehydrogenase for an Amperometric Sensor Constituent
Koji Sode, Tokyo University of Agriculture and Technology, JAPAN

15:00 - 15:15 Homology-independent Protein Engineering Using Incremental Truncation
Technology
Stefan Lutz, The Pennsylvania State University, USA

15:15 - 15:30 Creation of Protein/Enzyme Lineages with New Sequence Spaces by
Functional Salvage Screen
Hak-Sung Kim, Korea Advanced Institute of Science and Technology, Taejon, KOREA

15:30 - 15:45 Controlling Factors in Bacterial Cell-Free Protein Biosynthesis
Martin Siemann-Herzberg, University of Stuttgart, GERMANY

15:45 - 16:00 Development of Single-Molecule PCR Combined with Cell-Free Protein
Synthesis to Construct Large in-vitro Protein Library
Tsuneo Yamane, Nagoya University, JAPAN

16:00 - 16:15 Cell-Free Protein Expression: New Developments and Challenges
Erhard Fernholz, Roche Diagnostics, Penzberg, GERMANY

16:15 - 16:30 Cell Surface Engineering of Yeast - How to Apply It
Atsuo Tanaka, Kyoto University, JAPAN

16:30 - 17:00 Coffee Break

17:00 - 18.45 SESSION VII: ORAL PRESENTATION OF SELECTED POSTERS
Session Co-Chairs:
Harvey W. Blanch, University of California, Berkeley, USA
Hak-Sung Kim, Korea Advanced Institute of Science and Technology, Taejon, KOREA

17:00 - 17:10 Poster Chair: Introduction of Poster Prize Winners

17:10 - 17:30 TBA, Presentation of Poster (Second Prize)

17:30 - 17:50 TBA., Presentation of Poster (First Prize)

ENZYME ENGINEERING AWARD LECTURE
Session Chair:
Maria-Regina Kula, Heinrich Heine University of Düsseldorf, GERMANY

17:50 - 18:00 Maria-Regina Kula
Introduction of Enzyme Engineering Award Winner

18:00 - 18:45 2001 Enzyme Engineering Award Lecture

19:15 - 22.00 Banquet

Friday, October 12, 2001

07:00 - 09:00 Breakfast and Conference Adjournment

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